Battery:Article Title: Cognitive Performance in Parkinson’s Disease in the Brain Health Registry
Article Snippet: Our results thus 267 support that online screening methods developed to 268 U nc or re ct ed A ut ho r P ro of Table 3 Cognitive measures, PD versus Non-PD Domain Mean (sd) range OR∗ 95% CI P PD Non-PD Cogstate Brief Battery One-Back Attention & working memory (reaction time, log10 transformed) 2.88 (0.10) 2.88 (0.09) 1.01 0.92–1.11 0.813 2.51–3.20 2.44–3.69 One Card Learning Visual learning & memory (accuracy, arcsine transformation of the square root) 0.70 (0.16) 0.76 (0.17) 1.32 1.13–1.54 0.001† 0.18 – 1.18 0.03 – 1.41 Identification Visual attention (reaction time, log10 transformed) 2.72 (0.08) 2.71 (0.06) 1.20 1.10–1.31 <0.001† 2.52–3.05 2.37–3.19 Detection Processing speed (reaction time log10 transformed) 2.58 (0.10) 2.56 (0.10) 1.30 1.19–1.42 <0.001† 2.19–3.16 2.01–3.49 MemTrax Visual recognition memory (correct response reaction time, s) 0.97 (0.22) 0.95 (0.21) 1.16 1.05–1.28 0.005† 0.57–1.91 0.49–2.00 Neurocognitive Performance Test Go/No Go Response inhibition & processing speed (mean reaction time, s) 0.51 (0.10) 0.50 (0.09) 1.09 1.00–1.19 0.062 0.32–1.00 0.26–1.28 Trailmaking Part B Spatial working memory/divided attention (time to complete, seconds) 62.76 (39.06) 55.88 (33.95) 1.18 1.09–1.27 <0.001† 23.34–286.11 16.32–297.56 Forward Memory Span Spatial attention (total correct) 4.86 (1.37) 4.98 (1.23) 1.12 1.03–1.22 0.010 0–8 0–9 Reverse Memory Span Spatial working memory (total correct) 4.13 (1.62) 4.22 (1.56) 1.08 1.00–1.18 0.088 0–8 0–9 ∗Controlling for age, education level, sex, and Geriatric Depression Scale score; ORs based on conversion of test scores to a standardized scale (standard deviation = 1) to facilitate comparison across measures; †Met criteria for significance using the Bonferroni adjustment (0.006); CI, confidence interval; OR, odds ratio; PD, Parkinson’s disease; sd, standard deviation. improve recruitment into AD clinical trials by the269 BHR may also help identify, recruit, and evaluate270 research participants with PD.271 Our results show that the BHR is an effective272 method for recruitment of research participants with273 self-reported PD, possibly by overcoming known274 obstacles to participation.
Transformation Assay:Article Title: Cognitive Performance in Parkinson’s Disease in the Brain Health Registry
Article Snippet: Our results thus 267 support that online screening methods developed to 268 U nc or re ct ed A ut ho r P ro of Table 3 Cognitive measures, PD versus Non-PD Domain Mean (sd) range OR∗ 95% CI P PD Non-PD Cogstate Brief Battery One-Back Attention & working memory (reaction time, log10 transformed) 2.88 (0.10) 2.88 (0.09) 1.01 0.92–1.11 0.813 2.51–3.20 2.44–3.69 One Card Learning Visual learning & memory (accuracy, arcsine transformation of the square root) 0.70 (0.16) 0.76 (0.17) 1.32 1.13–1.54 0.001† 0.18 – 1.18 0.03 – 1.41 Identification Visual attention (reaction time, log10 transformed) 2.72 (0.08) 2.71 (0.06) 1.20 1.10–1.31 <0.001† 2.52–3.05 2.37–3.19 Detection Processing speed (reaction time log10 transformed) 2.58 (0.10) 2.56 (0.10) 1.30 1.19–1.42 <0.001† 2.19–3.16 2.01–3.49 MemTrax Visual recognition memory (correct response reaction time, s) 0.97 (0.22) 0.95 (0.21) 1.16 1.05–1.28 0.005† 0.57–1.91 0.49–2.00 Neurocognitive Performance Test Go/No Go Response inhibition & processing speed (mean reaction time, s) 0.51 (0.10) 0.50 (0.09) 1.09 1.00–1.19 0.062 0.32–1.00 0.26–1.28 Trailmaking Part B Spatial working memory/divided attention (time to complete, seconds) 62.76 (39.06) 55.88 (33.95) 1.18 1.09–1.27 <0.001† 23.34–286.11 16.32–297.56 Forward Memory Span Spatial attention (total correct) 4.86 (1.37) 4.98 (1.23) 1.12 1.03–1.22 0.010 0–8 0–9 Reverse Memory Span Spatial working memory (total correct) 4.13 (1.62) 4.22 (1.56) 1.08 1.00–1.18 0.088 0–8 0–9 ∗Controlling for age, education level, sex, and Geriatric Depression Scale score; ORs based on conversion of test scores to a standardized scale (standard deviation = 1) to facilitate comparison across measures; †Met criteria for significance using the Bonferroni adjustment (0.006); CI, confidence interval; OR, odds ratio; PD, Parkinson’s disease; sd, standard deviation. improve recruitment into AD clinical trials by the269 BHR may also help identify, recruit, and evaluate270 research participants with PD.271 Our results show that the BHR is an effective272 method for recruitment of research participants with273 self-reported PD, possibly by overcoming known274 obstacles to participation.
Inhibition:Article Title: Cognitive Performance in Parkinson’s Disease in the Brain Health Registry
Article Snippet: Our results thus 267 support that online screening methods developed to 268 U nc or re ct ed A ut ho r P ro of Table 3 Cognitive measures, PD versus Non-PD Domain Mean (sd) range OR∗ 95% CI P PD Non-PD Cogstate Brief Battery One-Back Attention & working memory (reaction time, log10 transformed) 2.88 (0.10) 2.88 (0.09) 1.01 0.92–1.11 0.813 2.51–3.20 2.44–3.69 One Card Learning Visual learning & memory (accuracy, arcsine transformation of the square root) 0.70 (0.16) 0.76 (0.17) 1.32 1.13–1.54 0.001† 0.18 – 1.18 0.03 – 1.41 Identification Visual attention (reaction time, log10 transformed) 2.72 (0.08) 2.71 (0.06) 1.20 1.10–1.31 <0.001† 2.52–3.05 2.37–3.19 Detection Processing speed (reaction time log10 transformed) 2.58 (0.10) 2.56 (0.10) 1.30 1.19–1.42 <0.001† 2.19–3.16 2.01–3.49 MemTrax Visual recognition memory (correct response reaction time, s) 0.97 (0.22) 0.95 (0.21) 1.16 1.05–1.28 0.005† 0.57–1.91 0.49–2.00 Neurocognitive Performance Test Go/No Go Response inhibition & processing speed (mean reaction time, s) 0.51 (0.10) 0.50 (0.09) 1.09 1.00–1.19 0.062 0.32–1.00 0.26–1.28 Trailmaking Part B Spatial working memory/divided attention (time to complete, seconds) 62.76 (39.06) 55.88 (33.95) 1.18 1.09–1.27 <0.001† 23.34–286.11 16.32–297.56 Forward Memory Span Spatial attention (total correct) 4.86 (1.37) 4.98 (1.23) 1.12 1.03–1.22 0.010 0–8 0–9 Reverse Memory Span Spatial working memory (total correct) 4.13 (1.62) 4.22 (1.56) 1.08 1.00–1.18 0.088 0–8 0–9 ∗Controlling for age, education level, sex, and Geriatric Depression Scale score; ORs based on conversion of test scores to a standardized scale (standard deviation = 1) to facilitate comparison across measures; †Met criteria for significance using the Bonferroni adjustment (0.006); CI, confidence interval; OR, odds ratio; PD, Parkinson’s disease; sd, standard deviation. improve recruitment into AD clinical trials by the269 BHR may also help identify, recruit, and evaluate270 research participants with PD.271 Our results show that the BHR is an effective272 method for recruitment of research participants with273 self-reported PD, possibly by overcoming known274 obstacles to participation.
Standard Deviation:Article Title: Cognitive Performance in Parkinson’s Disease in the Brain Health Registry
Article Snippet: Our results thus 267 support that online screening methods developed to 268 U nc or re ct ed A ut ho r P ro of Table 3 Cognitive measures, PD versus Non-PD Domain Mean (sd) range OR∗ 95% CI P PD Non-PD Cogstate Brief Battery One-Back Attention & working memory (reaction time, log10 transformed) 2.88 (0.10) 2.88 (0.09) 1.01 0.92–1.11 0.813 2.51–3.20 2.44–3.69 One Card Learning Visual learning & memory (accuracy, arcsine transformation of the square root) 0.70 (0.16) 0.76 (0.17) 1.32 1.13–1.54 0.001† 0.18 – 1.18 0.03 – 1.41 Identification Visual attention (reaction time, log10 transformed) 2.72 (0.08) 2.71 (0.06) 1.20 1.10–1.31 <0.001† 2.52–3.05 2.37–3.19 Detection Processing speed (reaction time log10 transformed) 2.58 (0.10) 2.56 (0.10) 1.30 1.19–1.42 <0.001† 2.19–3.16 2.01–3.49 MemTrax Visual recognition memory (correct response reaction time, s) 0.97 (0.22) 0.95 (0.21) 1.16 1.05–1.28 0.005† 0.57–1.91 0.49–2.00 Neurocognitive Performance Test Go/No Go Response inhibition & processing speed (mean reaction time, s) 0.51 (0.10) 0.50 (0.09) 1.09 1.00–1.19 0.062 0.32–1.00 0.26–1.28 Trailmaking Part B Spatial working memory/divided attention (time to complete, seconds) 62.76 (39.06) 55.88 (33.95) 1.18 1.09–1.27 <0.001† 23.34–286.11 16.32–297.56 Forward Memory Span Spatial attention (total correct) 4.86 (1.37) 4.98 (1.23) 1.12 1.03–1.22 0.010 0–8 0–9 Reverse Memory Span Spatial working memory (total correct) 4.13 (1.62) 4.22 (1.56) 1.08 1.00–1.18 0.088 0–8 0–9 ∗Controlling for age, education level, sex, and Geriatric Depression Scale score; ORs based on conversion of test scores to a standardized scale (standard deviation = 1) to facilitate comparison across measures; †Met criteria for significance using the Bonferroni adjustment (0.006); CI, confidence interval; OR, odds ratio; PD, Parkinson’s disease; sd, standard deviation. improve recruitment into AD clinical trials by the269 BHR may also help identify, recruit, and evaluate270 research participants with PD.271 Our results show that the BHR is an effective272 method for recruitment of research participants with273 self-reported PD, possibly by overcoming known274 obstacles to participation.
Comparison:Article Title: Cognitive Performance in Parkinson’s Disease in the Brain Health Registry
Article Snippet: Our results thus 267 support that online screening methods developed to 268 U nc or re ct ed A ut ho r P ro of Table 3 Cognitive measures, PD versus Non-PD Domain Mean (sd) range OR∗ 95% CI P PD Non-PD Cogstate Brief Battery One-Back Attention & working memory (reaction time, log10 transformed) 2.88 (0.10) 2.88 (0.09) 1.01 0.92–1.11 0.813 2.51–3.20 2.44–3.69 One Card Learning Visual learning & memory (accuracy, arcsine transformation of the square root) 0.70 (0.16) 0.76 (0.17) 1.32 1.13–1.54 0.001† 0.18 – 1.18 0.03 – 1.41 Identification Visual attention (reaction time, log10 transformed) 2.72 (0.08) 2.71 (0.06) 1.20 1.10–1.31 <0.001† 2.52–3.05 2.37–3.19 Detection Processing speed (reaction time log10 transformed) 2.58 (0.10) 2.56 (0.10) 1.30 1.19–1.42 <0.001† 2.19–3.16 2.01–3.49 MemTrax Visual recognition memory (correct response reaction time, s) 0.97 (0.22) 0.95 (0.21) 1.16 1.05–1.28 0.005† 0.57–1.91 0.49–2.00 Neurocognitive Performance Test Go/No Go Response inhibition & processing speed (mean reaction time, s) 0.51 (0.10) 0.50 (0.09) 1.09 1.00–1.19 0.062 0.32–1.00 0.26–1.28 Trailmaking Part B Spatial working memory/divided attention (time to complete, seconds) 62.76 (39.06) 55.88 (33.95) 1.18 1.09–1.27 <0.001† 23.34–286.11 16.32–297.56 Forward Memory Span Spatial attention (total correct) 4.86 (1.37) 4.98 (1.23) 1.12 1.03–1.22 0.010 0–8 0–9 Reverse Memory Span Spatial working memory (total correct) 4.13 (1.62) 4.22 (1.56) 1.08 1.00–1.18 0.088 0–8 0–9 ∗Controlling for age, education level, sex, and Geriatric Depression Scale score; ORs based on conversion of test scores to a standardized scale (standard deviation = 1) to facilitate comparison across measures; †Met criteria for significance using the Bonferroni adjustment (0.006); CI, confidence interval; OR, odds ratio; PD, Parkinson’s disease; sd, standard deviation. improve recruitment into AD clinical trials by the269 BHR may also help identify, recruit, and evaluate270 research participants with PD.271 Our results show that the BHR is an effective272 method for recruitment of research participants with273 self-reported PD, possibly by overcoming known274 obstacles to participation.
Clinical Proteomics:Article Title: Cognitive Performance in Parkinson’s Disease in the Brain Health Registry
Article Snippet: Our results thus 267 support that online screening methods developed to 268 U nc or re ct ed A ut ho r P ro of Table 3 Cognitive measures, PD versus Non-PD Domain Mean (sd) range OR∗ 95% CI P PD Non-PD Cogstate Brief Battery One-Back Attention & working memory (reaction time, log10 transformed) 2.88 (0.10) 2.88 (0.09) 1.01 0.92–1.11 0.813 2.51–3.20 2.44–3.69 One Card Learning Visual learning & memory (accuracy, arcsine transformation of the square root) 0.70 (0.16) 0.76 (0.17) 1.32 1.13–1.54 0.001† 0.18 – 1.18 0.03 – 1.41 Identification Visual attention (reaction time, log10 transformed) 2.72 (0.08) 2.71 (0.06) 1.20 1.10–1.31 <0.001† 2.52–3.05 2.37–3.19 Detection Processing speed (reaction time log10 transformed) 2.58 (0.10) 2.56 (0.10) 1.30 1.19–1.42 <0.001† 2.19–3.16 2.01–3.49 MemTrax Visual recognition memory (correct response reaction time, s) 0.97 (0.22) 0.95 (0.21) 1.16 1.05–1.28 0.005† 0.57–1.91 0.49–2.00 Neurocognitive Performance Test Go/No Go Response inhibition & processing speed (mean reaction time, s) 0.51 (0.10) 0.50 (0.09) 1.09 1.00–1.19 0.062 0.32–1.00 0.26–1.28 Trailmaking Part B Spatial working memory/divided attention (time to complete, seconds) 62.76 (39.06) 55.88 (33.95) 1.18 1.09–1.27 <0.001† 23.34–286.11 16.32–297.56 Forward Memory Span Spatial attention (total correct) 4.86 (1.37) 4.98 (1.23) 1.12 1.03–1.22 0.010 0–8 0–9 Reverse Memory Span Spatial working memory (total correct) 4.13 (1.62) 4.22 (1.56) 1.08 1.00–1.18 0.088 0–8 0–9 ∗Controlling for age, education level, sex, and Geriatric Depression Scale score; ORs based on conversion of test scores to a standardized scale (standard deviation = 1) to facilitate comparison across measures; †Met criteria for significance using the Bonferroni adjustment (0.006); CI, confidence interval; OR, odds ratio; PD, Parkinson’s disease; sd, standard deviation. improve recruitment into AD clinical trials by the269 BHR may also help identify, recruit, and evaluate270 research participants with PD.271 Our results show that the BHR is an effective272 method for recruitment of research participants with273 self-reported PD, possibly by overcoming known274 obstacles to participation.
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